Factors Associated With Improved Glycemic Control Following Continuous Subcutaneous Insulin Infusion Therapy in Patients With Type 2 Diabetes Uncontrolled With Bolus-Basal Insulin Regimens: An Analysis From the OpT2mise Randomized Trial
April 4, 2017. This analysis investigated factors associated with A1C decreases in patients receiving continuous subcutaneous insulin infusion (CSII) as part of the OpT2mise randomized trial. Patients with type 2 diabetes (T2D) and A1C levels >8% following multiple daily injection (MDI) optimization were randomized to receive CSII (n=168) or MDI (n=163) for 6 months. Investigators found that CSII produced a significantly greater reduction in A1C versus MDI; this treatment difference was more pronounced in patients with higher baseline A1C. These findings suggest that CSII offers an option to improve glycemic control in patients with T2D who cannot achieve blood glucose control with MDI.