Glycemic Control and Hypoglycemia With New Insulin Glargine 300 U/mL vs Glargine 100 U/mL in Patients With Type 2 Diabetes Using Basal Insulin and Oral Antihyperglycemic Drugs

July, 2015

This randomized, multicenter, open-label, two-arm study compared the efficacy of insulin glargine 300 U/mL (Gla-300) vs 100 U/mL (Gla-100) in patients with type 2 diabetes treated with basal insulin and oral antihyperglycemic drugs (excluding sulfonylureas). The study (EDITION 2) was conducted over 12 months. Both Gla-300 and Gla-100 were associated with A1C reductions from baseline (-0.55% vs -0.50%, respectively). Patients receiving Gla-300 had a significant 37% relative reduction in confirmed nocturnal hypoglycemia (P=0.031), as well as significantly less weight gain (mean difference, 0.7 kg; P=0.009) compared with Gla-100. The full study abstract is available at this link.