Initial Combination Treatment With Empagliflozin and Linagliptin in Patients With Type 2 Diabetes

January 29, 2015. This study randomized antihyperglycemic drug-naïve patients (N=677) with type 2 diabetes to 52 weeks of treatment with 1 of 5 regimens: empagliflozin (EMP) 25 mg + linagliptin (LIN) 5 mg; EMP 10 mg + LIN 5 mg; EMP 25 mg; EMP 10 mg; or LIN 5 mg.  The primary endpoint was change in A1C from baseline to week 24; patients’ mean baseline A1C levels were 7.99% to 8.05%. At week 24, patients had the following A1C reductions: EMP 25 mg + LIN 5 mg, -1.08% (P <0.001 vs LIN 5 mg); EMP 10 mg + LIN 5 mg, -1.24% (P <0.001 vs EMP 10 mg and LIN 5 mg); EMP 25 mg, -0.95%; EMP 10 mg, -0.83%, and LIN 5 mg -0.67%. Investigators reported that combined treatment with EMP + LIN was well tolerated. You can follow this link to ready the study abstract.