Insulin-Requiring Versus Noninsulin-Requiring Diabetes and Thromboembolic Risk in Patients With Atrial Fibrillation
January 31, 2017. This prospective, real-world, multicenter study evaluated the impact of insulin vs no insulin therapy on thromboembolic risk in patients with diabetes and atrial fibrillation (AF) being treated with anticoagulation therapy. Rates of stroke and systemic embolism were compared over 1 year based on patient diabetes and insulin use status. After controlling for confounders, investigators found a significantly increased rate of stroke and systemic embolism in patients with diabetes who were using insulin (5.2%) compared to patients with no diabetes (1.9%) or patients with diabetes but no insulin use (1.8%). The investigators noted that risk was similar between patients without diabetes and with diabetes but not receiving insulin.