Lowest Glucose Variability and Hypoglycemia Are Observed With the Combination of a GLP-1 Receptor Agonist and Basal Insulin (VARIATION Study)

January, 2017
February 2017. This cohort analysis evaluated the glucose variability (GV) and the hypoglycemia rates (defined as blood glucose less than 70 mg/dL) associated with 4 common insulin regimens in patients with type 2 diabetes. Patients (N=160) were recruited from endocrinology clinics and were required to be on a stable insulin regimen for a minimum of 6 months with A1C levels ≤7.5%. Data were obtained from continuous glucose monitoring for the following treatment regimens: basal insulin with oral antihyperglycemic drugs; basal insulin with a glucagon-like receptor 1 (GLP-1) receptor agonist; premixed insulin; and basal-bolus insulin. The lowest GV and hypoglycemia rates were observed in patients receiving the GLP-1 receptor agonist with insulin.