Lowest Glucose Variability and Hypoglycemia Are Observed With the Combination of a GLP-1 Receptor Agonist and Basal Insulin (VARIATION Study)
February 2017. This cohort analysis evaluated the glucose variability (GV) and the hypoglycemia rates (defined as blood glucose less than 70 mg/dL) associated with 4 common insulin regimens in patients with type 2 diabetes. Patients (N=160) were recruited from endocrinology clinics and were required to be on a stable insulin regimen for a minimum of 6 months with A1C levels ≤7.5%. Data were obtained from continuous glucose monitoring for the following treatment regimens: basal insulin with oral antihyperglycemic drugs; basal insulin with a glucagon-like receptor 1 (GLP-1) receptor agonist; premixed insulin; and basal-bolus insulin. The lowest GV and hypoglycemia rates were observed in patients receiving the GLP-1 receptor agonist with insulin.