Rates of Hypoglycemia Are Lower in Patients Treated With Insulin Degludec/Liraglutide Than With Insulin Degludec or Insulin Glargine Regardless of the Hypoglycemia Definition Used

April, 2017

April 17, 2017. Reported hypoglycemia rates in clinical trials have been shown to vary based on the hypoglycemia definition used. This post-hoc analysis applied data from the DUAL I and DUAL V trials, which compared once-daily, fixed ratio insulin degludec/liraglutide (IDegLira) vs the basal insulin regimens degludec and glargine. These data were re-analyzed using two definitions of hypoglycemia (confirmed hypoglycemia and American Diabetes Association-documented symptomatic hypoglycemia). Patients receiving IDegLira had lower rates of confirmed hypoglycemia and nocturnal hypoglycemia regardless of the hypoglycemia definition used. Findings did not vary based on the time of day when IDegLira was administered and were not affected when results were stratified for baseline age, gender, or body mass index. Click here for full article