Risk Factors for Severe Hypoglycemia in Adults With Diabetes

Date: 
December, 2017

December 1, 2017. Assessing hypoglycemia risk is essential when individualizing diabetes care. This studied aimed to evaluate risk factors for severe hypoglycemia over a median 15.2 years among 1,206 participants with diabetes, using data from the ongoing, prospective Atherosclerosis Risk in Communities (ARIC) cohort study. Mean participant age was 64 years, 46% were male, and 32% were black. Using hospitalization, emergency department visit, and ambulance use claims from 1996-2013, the following risk factors were identified: age (per 5 years; hazard ratio [HR] 1.24; 95% confidence interval [CI] 1.07-1.43), black race (HR 1.39; 95% CI 1.02-1.88), insulin use vs no medications and oral medications only vs no medications (HR 3.00; 95% CI 1.71-5.28 and HR 2.20; 95% CI 1.28-3.76, respectively), poor vs good and moderate vs good glycemic control (HR 2.62; 95% CI 1.67-4.10 and HR 1.78; 95% CI 1.11-2.83, respectively), macroalbuminuria (HR 1.95; 95% CI 1.23-3.07), and poor cognitive function (HR 1.57; 95% CI 1.33-1.84). Low 1,5-anhydroglucitol, use of Medicaid insurance, difficulty with activities of daily living, and antidepressant use were also associated with an increased risk of severe hypoglycemia. Read the abstract here.